Scientists won the Nobel Prize for gene editing technology used to successfully eliminate infected HIV

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According to a BBC report on the 20th, researchers at the University of Amsterdam in the Netherlands said at a medical conference held on the 18th that they successfully removed the HIV virus (HIV) from infected cells using CRISPR gene editing technology.

Screenshots of related reports

It is reported that although existing drugs can prevent the HIV virus from further penetrating into the human body, they cannot clear the existing virus in the patient’s body. Even if patients receive effective treatment and the HIV virus in their bodies enters a dormant or latent state, they still carry HIV DNA or genetic material.

According to the BBC, the CRISPR gene editing technology used by the researchers is similar in principle to scissors, which can remove or inactivate HIV-infected cells by cutting DNA. This gene editing technology won the 2020 Nobel Prize in Chemistry.

At present, the scientific research process at the University of Amsterdam is still in the proof-of-concept stage, and it will take a long time for it to be truly applied to AIDS treatment.

Scientists believe that if this new technology can be further developed, it will be expected to eliminate all HIV in the human body, thereby curing AIDS. However, some virologists also said that the possible off-target effects and long-term side effects of this technology are worrying.

Wen| Reporter Leng Shuang

2024 _Thirsty Lion_ joint military exercise held in Jordan_ 33 countries participated

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Amman, May 12 (Reporter He Yiping) The Jordanian Armed Forces announced on the 12th the start of the 2024 Thirsty Lion Joint Military Exercise. The military exercise will last until the 23rd, with 33 countries including the United States and Jordan participating.

Jordanian Armed Forces spokesman Mustafa Shiari said at a press conference on the same day that the thirsty lion joint military exercise is one of the most important military exercises in the Middle East. In addition to the sea, land and air forces of the participating countries, there are also some government and non-governmental agencies and humanitarian organizations participate. The military exercise will be held in northern, central and southern Jordan. It is the largest since the launch of the Kashi Lion joint military exercise, but it has nothing to do with the regional situation.

It is reported that this military exercise aims to allow participating countries to reach consensus on combating emerging and cross-border threats such as terrorist organizations and their supporters, the proliferation of drones and weapons of mass destruction, and find the best response methods and means. At the same time, coordinate the participating countries ‘action plans and goals in land, sea and air military operations, logistics support, response to natural disasters and epidemics.

Jordan has held the Thirsty Lion joint military exercise since 2011 and is held once a year except for suspension in 2020, 2021 and 2023. This year is the 11th time that Jordan has held the thirsty lion joint military exercise.

Russian man threw cigarette butts into the sewer and killed himself_ and the nearby cameras were hit and tilted.

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According to the Tass news agency, a man threw a cigarette butt into the sewer in Hasavur, Republic of Dagestan, Russia, and caused an explosion, killing himself and his companions.

According to reports, surveillance footage showed that at the time of the incident, the man and his companion parked the car on the roadside, got off the bus and smoked together, and then threw the cigarette butts into the sewer. Subsequently, the cigarette butts ignited the gas in the sewer, causing a violent explosion. The two people were killed on the spot, and even the nearby cameras were tilted.

Reported that failure to follow safety precautions resulted in an explosion of acetylene gas-air mixture in the sewer.

According to preliminary information obtained from the investigation, the two men were housing and public service employees and were doing technical work in a nearby residential building.

Currently, the local police are handling the incident.

Wen| Reporter Leng Shuang

Russian official_ US authorizes Ukraine to launch new attacks on Russian territory

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According to a report by the Tass news agency on July 17, Alexei Polisyuk, Director of the Second Department of CIS Affairs of the Russian Ministry of Foreign Affairs, told the Tass news agency that the United States has authorized Ukraine President Zelensky to launch a new strike on Russian territory.

Polisiuk pointed out: Washington is still fueling the escalation of the situation. They tried to justify their crimes while defending Kiev. Not only that, the Zelensky regime was also granted full powers to use American weapons to carry out new strikes on Russian territory.

He emphasized that the United States is still indulging in the dream of its own superior position, hoping that if Russia suffers strategic failure, it can safely hide across the ocean. He warned: Few among the American elite are aware of the risks of such arrogant and underestimating opponents ‘self-deception. For the United States and the world, the consequences may be unpredictable.

Polisiuk emphasized that behind the missile attack on Sevastopol, there was no doubt that U.S. military experts were providing various support services. They used the Pentagon’s drones circling over the area to target targets. (Russia) has made the most solemn representations to the U.S. ambassador to Moscow and the U.S. authorities in this regard, sending the clearest signal that terrorist attacks will lead to inevitable retaliation. As for the safety of the Crimean Peninsula and local residents, this is an absolute priority, and (Russia) is doing its best to provide reliable security. (Compiled by Tong Shiqun)

Israeli army says operation Shifa hospital will not end until all Palestinian militants are captured

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Jerusalem, March 23 (Reporters Wang Zhuolun and Lu Yingxu) The Israel Defense Forces issued a situation report on the 23rd, saying that only when all Palestinian militants at Shifa Hospital in Gaza City are captured will the Israeli army end its military operations in the Gaza Strip, the largest hospital.

The report quoted Finkelman, commander of the Israel Defense Forces ‘Southern Military Region, as saying that the Israeli army’s operation at Shifa Hospital is important and complex. The Israeli army is continuing this operation until the last Palestinian militant falls into the Israeli army’s hands, whether alive or dead. The Israeli army’s operation at Shifa Hospital will not end.

Earlier in the day, the Israeli army issued a situation report saying that the Israeli army had killed more than 170 Palestinian militants and arrested more than 800 suspects during its operation at Shifa Hospital. The Israeli army found weapons and facilities of Palestinian armed groups in the hospital. The sick and wounded in Shifa Hospital have been evacuated to designated compounds, and the Israeli army has also assisted trucks carrying medical equipment, food and water into the hospital.

Palestinian official news agency Wafa quoted Gaza medical sources as saying on the 23rd that Shifa Hospital was in harsh conditions and lacked water, food and medical services. Five Palestinian patients died that day. The Israeli army arrested about 240 patients and their caregivers, as well as 10 medical staff inside the hospital complex.

On the 18th of this month, Israeli troops invaded Shifa Hospital and issued a statement saying that intelligence showed that Palestinian Islamic Resistance Movement (Hamas) militants had recently entered Shifa Hospital and used the hospital as a command center. The Israeli army took military action against Shifa Hospital in November last year and claimed that Hamas ‘combat command center and military equipment were found in the hospital. The Gaza Strip health department denied this.

Uzbek MP_ Macron is considering sending troops with a _firm attitude_ Russia_ It is not difficult to eliminate the French army in Uzbekistan

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According to a report by Russia’s “Labor” on March 20, Alexei Goncharenko, a member of the Verkhovna Rada (Parliament) of Ukraine, said on the 20th that the French government is considering sending troops to the Ukraine border to help the Ukrainian army liberate its troops.

The report said that the Ukraine lawmaker said he learned the news from his French counterpart at the Parliamentary Assembly of the Council of Europe.

He emphasized that discussions on France sending troops to Ukraine are indeed ongoing.

Gonchalenko also said that the number of this force is not yet certain. However, French President Macron is very firm.

Goncharenko said France was forming an alliance and Poland and the Baltic states might join. Another option is to establish a base in western Ukraine, where Ukrainian soldiers can be trained and artillery shells produced.

The report mentioned that the French Ministry of Defense issued a statement a day ago saying that Russian Foreign Intelligence Agency Director Naryshkin’s statement that the French leadership was preparing to send 2000 soldiers to Ukraine was spreading rumors. At the same time, the news that there were French soldiers in Ukraine was also false. Russian Foreign Ministry spokesperson Zakharova immediately responded to the Paris statement. She wrote on the Telegraph social platform: Has the French government abandoned its citizens again?(Compiled by He Yingjun)

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Medvedev: Eliminating French forces in Ukraine is not difficult

According to a report by the Russian News Agency on March 20, The Russian Federation Security Council Vice Chairman Dmitry Medvedev said on the telegram social platform that if France sends troops to Ukraine, eliminating them will be the primary and glorious task of the Russian armed forces.

According to reports, Medvedev believes that it is difficult for the French army to hide its traces in Ukraine, so it is not difficult to eliminate them, and it is impossible to conceal the large number of deaths of French professional soldiers.

Medvedev wrote on the Telegraph social platform: These unfortunate people will become official combatants of the (foreign) intervention force. Eliminating them will be the primary and glorious task of our armed forces.

Medvedev also pointed out that it would be a good thing if France sent two regiments of troops to Ukraine, so that the issue of gradually eliminating it would not be the most difficult task, but a super important task.

Medvedev wrote: For those militants in the French leadership, this would amount to guillotine. Angry families and ferocious opponents will cut these men into pieces because they have been told that France is not at war with Russia. This will be a good lesson for other restless European fools.

Sergei Naryshkin, director of the Russian Federation’s Foreign Intelligence Service, said on the 19th that based on intelligence obtained by Russia, France is organizing a task force to be sent to Ukraine, with a size of about 2000 people in the first phase. (Compiled by Liu Yang)

Putin_ Ukrainian troops attack Russia in an attempt to disrupt Russian presidential election vote

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Moscow, March 15th Russian President Vladimir Putin said on the 15th that the Ukraine army has tried repeatedly to attack Russia in recent days without success. The Ukrainian army has tried to disrupt the Russian presidential election vote through attacks.

When Putin held a video meeting with members of the Russian Security Council that day, he said that from the 12th to the present, Uzbekistan has mainly used special forces, foreign mercenaries and Ukrainian military support forces to repeatedly attempt to enter Russian territory and create many sabotage and terrorist attacks. Four of them occurred in the direction of Belgorod and one occurred in the direction of Kursk.

Putin said that the Ukrainian army used more than 2500 people, 35 tanks and 40 armored vehicles for this purpose, but it was unsuccessful and as a result, it lost 60% of its personnel and more than 50% of its armored equipment.

He also stressed that the Ukrainian army’s above-mentioned actions are meaningless from a military perspective and criminal from a humanitarian perspective. The purpose is to disrupt the Russian presidential election voting process and intimidate Russian civilians in the area bordering Ukraine.

The Russian Ministry of Defense issued a notice on the 15th, saying that from the 12th to the 14th, the Russian armed forces, together with the border defense department of the Russian Federal Security Service, thwarted Ukrainian armed men’s incursion into the territory of the Russian Belgorod and Kursk Oblast. Uzbekistan lost more than 1500 soldiers in the operation, of which about 500 were killed, and 18 tanks and 23 armored vehicles were destroyed.

The official voting for the 2024 Russian presidential election will be held from the 15th to the 17th. According to the Russian president, Putin participated in the presidential election voting online on the 15th. (Reporter Huang He)

Most of the prisoners who escaped from prison in Niger have been captured

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Abidjan, July 14 (Reporter Zhang Jian) News from Niamey: Niger’s Defense and Security Forces issued a communiqué on the evening of the 13th, saying that most of the dozens of prisoners who recently escaped from the country’s Kutukare prison have been captured and three others were killed.

The communiqué said the area where the prison is located has been cordoned off and an aerial search operation is still underway to find the remaining fugitives. The military called on the public to be vigilant and immediately report any suspicious person or any relevant information to the authorities.

On the evening of the 11th, a prisoner escape occurred at Kutukare Prison in Tirabei Province, Tirabei Region, western Niger. The prison is located 50 kilometers northwest of Niamey, the capital of Niger, and holds members of extremist organizations such as the Boko Haram Islamic State. In 2016 and 2019, two jailbreaks occurred in this prison, both of which were successfully prevented.

Organic chemistry the molecular cornerstone of life

  Organic chemistry is an important branch of studying carbon compounds, involving the source, structure, properties and other aspects of organic matter, and providing revelation for the material basis of life phenomena. It plays a key role in medicine, industrial production and other fields, but it still faces challenges such as green synthesis and drug molecular selectivity. Organic chemists are constantly exploring new reaction mechanisms and synthetic methods to promote the development of the discipline.For the current market situation, inhibitors It has a very advantageous development prospect and an extremely superior ecological environment. https://www.all-chemistry.com/

  

  Generated by the author through intelligent technology

  

  In the vast universe of science, organic chemistry is like a bright star, leading us to explore the mystery of life. As a subject of studying carbon compounds, organic chemistry, with its unique charm, closely links all fields of natural science and reveals the material basis of life phenomena for us. Organic chemistry, an important branch of chemistry, is a subject that studies the source, structure, properties, separation, preparation, application and related theories of organic matter. “Organic matter” here refers to compounds containing carbon elements, such as alcohols, aldehydes, carboxylic acids, etc. It is worth noting that although organic matter mainly comes from organisms, with the development of science and technology, people have been able to synthesize many artificial organic compounds with biological activity, such as drugs, dyes, plastics and so on.

  

  The main research contents of organic chemistry include: synthetic chemistry of organic matter; Metal organic chemistry and elemental organic chemistry; Physical and theoretical organic chemistry; Stereochemistry; Bioorganic chemistry; Natural product chemistry; Chemistry of organic materials.

  

  The importance of organic chemistry:

  

  1. Basis of life: From the origin of life to the growth and development of organisms, carbon always plays a vital role. Through the study of organic chemistry, we know the structure and function of biological macromolecules such as protein, nucleic acid, sugar and lipid, which are the material basis of life.

  

  2. Key in the field of medicine: Many drugs and bioactive substances are organic compounds, such as antibiotics, antiviral drugs and hormones. By studying the structure and function of these substances, scientists are constantly discovering new treatments to protect human health.

  

  3. The core of industrial production: Organic chemistry plays an important role in industrial production. For example, in the process of petroleum refining, heavy hydrocarbons in petroleum can be converted into light hydrocarbons by the action of catalysts; In the process of plastic synthesis, organic chemical reactions provide a steady stream of power for the plastic industry. Although organic chemistry has made remarkable achievements in many fields, it still faces many challenges.

  

  First of all, in environmental protection, how to realize green synthesis and reduce the discharge of harmful waste is an urgent problem for organic chemists.

  

  Secondly, in the field of medicine, how to improve the selectivity of drug molecules and reduce side effects is also a difficult problem to be solved urgently. Faced with these challenges, organic chemists are constantly exploring new reaction mechanisms, catalysts and synthetic methods. I believe that in the near future, organic chemistry will bring us more surprises and inject new vitality into the development of human society. Organic chemistry, as a discipline to study the molecular cornerstone of life, plays an important role in natural science. Let’s walk into this wonderful world hand in hand, grow in exploration, break through in innovation, and jointly write a bright future of organic chemistry.

Composition characteristics of protein

  Protein is a complex organic polymer compound composed of α -amino acids combined in a certain order to form a polypeptide chain, and then one or more polypeptide chains are combined in a specific way. Amino acids are the basic units of protein, and they are linked into peptide chains through dehydration and condensation. Each polypeptide chain has twenty to hundreds of amino acid residues (-R); Various amino acid residues are arranged in a certain order.know recombinant proteins The market will definitely bring great influence to the whole industry. https://www.alphalifetech.com/

  

  the composition characteristics of protein

  

  The amino acid sequence of protein is encoded by the corresponding gene. In addition to the 20 basic amino acids encoded by the genetic code, in protein, some amino acid residues can be modified after translation to change their chemical structure, thus activating or regulating protein. Multiple protein can form a stable protein complex together, often by combining together, and fold or spiral to form a certain spatial structure, thus playing a specific function. The organelles of synthetic peptides are ribosomes on rough endoplasmic reticulum in cytoplasm. The difference of protein lies in the variety, number, arrangement order of amino acids and the spatial structure of peptide chains.

  

  Protein is composed of C (carbon), H (hydrogen), O (oxygen) and N (nitrogen), and generally protein may also contain P (phosphorus), S (sulfur), Fe (iron), Zn (zinc), Cu (copper), B (boron), Mn (manganese) and I (iodine).

  

  The composition percentage of these elements in protein is about: 50% carbon, 7% hydrogen, 23% oxygen, 16% nitrogen, 0-3% sulfur and other trace amounts.

  

  All protein contains N element, and the nitrogen content of various protein is very close, with an average of 16%;

  

  Every 1g of N in any biological sample means that there is about 100/16=6.25g protein, and 6.25 is often called protein constant.